The literature is full of disputes, contradictions and confusions regarding acne. This disease is more prevailing among the young people and often associated with suicide and depression. Acne starts appearing after the onset of puberty and can extend up to 40 to 50 years of age. As far as pathogenesis of acne is concerned it is not fully understood up till now. The main key factors responsible for the development of acne are: An increased production of sebum, Hypercornification, Colonization of bacteria in pilosebaceous duct and Inflammation. Although inflammation is not directly associated with the development of acne but it can results as a consequence of other factors for example, propionibacterium acnes when colonized into the ducts it cause the production of pro inflammatory cytokines and other antigens which initiate various cellular as well as non- cellular immune responses ultimately lead to inflammation. Treatment of acne is very frustrating and involves an understanding of etiopathological factors. The aim of this review is to study the various factors responsible for acne, there contribution towards the pathogenesis of acne and acne therapy.
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